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Article

Identification of Significant Pathways Induced by PAX5 Haploinsufficiency Based on Protein-Protein Interaction Networks and Cluster Analysis in Raji Cell Line.

BioMed research international - 1 Jan 2017

Gu Jia, Li TongJuan, Zhao Lei, Liang Xue, Fu Xing, Wang Jue, Shang Zhen, Huang Wei, Zhou Jianfeng

Abstract excerpt

PAX5 encodes a transcription factor essential for B-cell differentiation, and PAX5 haploinsufficiency is involved in tumorigenesis. There were few studies on how PAX5 haploinsufficiency regulated genes expression to promote tumorigenesis. In this study, we constructed the cell model of PAX5 haploinsufficiency using gene editing technology in Raji cells, detected differentially expressed genes in PAX5...

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Identifiers

PMID: 28316978
DOI: 10.1155/2017/5326370
PMCID: PMC5339483

Genes

PAX5

Provenance

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