Article
MIR155 Regulation of Ubiquilin1 and Ubiquilin2: Implications in Cellular Protection and Tumorigenesis.
Neoplasia (New York, N.Y.) - 1 Apr 2017
Yadav Sanjay, Singh Nishant, Shah Parag P, Rowbotham David A, Malik Danial, Srivastav Ankita, Shankar Jai, Lam Wan L, Lockwood William W, Beverly Levi J
Abstract excerpt
Ubiquilin (UBQLN) proteins are adaptors thought to link ubiquitinated proteins to the proteasome. However, our lab has recently reported a previously unappreciated role for loss of UBQLN in lung cancer progression. In fact, UBQLN genes are lost in over 50% of lung cancer samples examined. However, a reason for the loss of UBQLN has not been proposed, nor has a selective pressure that could lead to deletion of...
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