Article
Cigarette Smoke Enhances the Malignant Phenotype of Esophageal Adenocarcinoma Cells by Disrupting a Repressive Regulatory Interaction Between miR-145 and LOXL2.
Laboratory investigation; a journal of technical methods and pathology - 1 Apr 2023
Xi Sichuan, Oyetunji Shakirat, Wang Haitao, Azoury Said, Liu Yi, Hsiao Shih-Hsin, Zhang Mary, Carr Shamus R, Hoang Chuong D, Chen Haobin, Schrump David S
Abstract excerpt
Although linked to esophageal carcinogenesis, the mechanisms by which cigarette smoke mediates initiation and progression of esophageal adenocarcinomas (EAC) have not been fully elucidated. In this study, immortalized esophageal epithelial cells and EAC cells (EACCs) were cultured with or without cigarette smoke condensate (CSC) under relevant exposure conditions. Endogenous levels of microRNA (miR)-145 and...
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