Article
Clinical Significance of FANCD2 Gene Expression and its Association with Tumor Progression in Hepatocellular Carcinoma.
Anticancer research - 1 Mar 2017
Komatsu Hisateru, Masuda Takaaki, Iguchi Tomohiro, Nambara Sho, Sato Kuniaki, Hu Quingjang, Hirata Hidenari, Ito Shuhei, Eguchi Hidetoshi, Sugimachi Keishi, Eguchi Hidetoshi, Doki Yuichiro, Mori Masaki, Mimori Koshi
Abstract excerpt
BACKGROUND/AIM: Fanconi anemia complementation group D2 (FANCD2) gene is vitally involved in DNA damage responses. We investigated the clinical significance of FANCD2 expression in hepatocellular carcinoma (HCC). PATIENTS AND METHODS: FANCD2 mRNA expression of resected HCC tissues was assessed in two HCC cohorts; Our cases (n=111), and The Cancer Genome Atlas (TCGA; n=371). Gene set enrichment analysis (GSEA) was...
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