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Article

Establishment of a novel cellular model for myxofibrosarcoma heterogeneity.

Scientific reports - 17 Mar 2017

Lohberger Birgit, Stuendl Nicole, Leithner Andreas, Rinner Beate, Sauer Stefan, Kashofer Karl, Liegl-Atzwanger Bernadette

Abstract excerpt

Human cancers frequently display substantial intra-tumoural heterogeneity in virtually all distinguishable phenotypic features, such as cellular morphology, gene expression, and metastatic potential. In order to investigate tumour heterogeneity in myxofibrosarcoma, we established a novel myxofibrosarcoma cell line with two well defined sub-clones named MUG-Myx2a and MUG-Myx2b. The parental tumour tissue and both...

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Source

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Identifiers

PMID: 28304377
DOI: 10.1038/srep44700
PMCID: PMC5356330

Genes

FGFR3
KDR
KIT
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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