Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis

16 Mar 2017

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that lacks a predictive and broadly applicable biomarker. Continued focus on mutation-specific upstream mechanisms has yet to predict disease progression in the clinic. Utilising cellular pathology common to the majority of ALS patients, we implemented an objective transcriptome-driven approach to develop noninvasive prognostic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28302159
DOI: 10.1186/s40478-017-0424-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosisPMID 28302159Read ↗

Identification of potentially functional modules and diagnostic genes related to amyotrophic lateral sclerosis based on the WGCNA and LASSO algorithmsSemantic proximity Read ↗

Characterization of the motor cortex transcriptome supports microgial-related key events in amyotrophic lateral sclerosisSemantic proximity Read ↗

Integrative genetic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genesSemantic proximity Read ↗

Human amyotrophic lateral sclerosis/motor neuron disease: The disease‐associated microglial pathway is upregulated while APOE genotype governs risk and survivalSemantic proximity Read ↗

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse ModelSemantic proximity Read ↗

Human amyotrophic lateral sclerosis/motor neuron disease: The disease-associated microglial pathway is upregulated and APOE ε2 is protectiveSemantic proximity Read ↗

TREM2 impacts brain microglia, oligodendrocytes and endothelial co-expression modules revealing genes and pathways important in Alzheimer’s diseaseSemantic proximity Read ↗

Motor cortex transcriptome reveals microglial key events in amyotrophic lateral sclerosisSemantic proximity Read ↗

Machine learning evaluation of gene expression-based ALS subtypes across brain and blood tissuesSemantic proximity Read ↗

Gene co-expression network analysis in human spinal cord highlights mechanisms underlying amyotrophic lateral sclerosis susceptibilitySemantic proximity Read ↗

Systematic analysis of cellular crosstalk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer’s diseaseSemantic proximity Read ↗

Gene co-expression network analysis in human spinal cord highlights mechanisms underlying amyotrophic lateral sclerosis susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.