Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FRZB and melusin, overexpressed in LGMD2A, regulate integrin β1D isoform replacement altering myoblast fusion and the integrin-signalling pathway.

Expert reviews in molecular medicine - 16 Mar 2017

Jaka Oihane, Casas-Fraile Leire, Azpitarte Margarita, Aiastui Ana, López de Munain Adolfo, Sáenz Amets

Abstract excerpt

Limb-girdle muscular dystrophy type 2A (LGMD2A) is characterised by muscle wasting and progressive degeneration of proximal muscles because of mutations in the CAPN3 gene. However, the underlying pathophysiological mechanisms of muscle degeneration are still not well understood. The objective of this study was to assess the relevance of genes with differential expression in the muscle of LGMD2A patients. For this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extracellular Matrix Proteins
Share to Integrins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lithium Chloride

Share to Muscle Fibers, Skeletal

Share to Muscle Proteins

Share to Muscular Dystrophies, Limb-Girdle

Share to Myoblasts

Share to Wnt Signaling Pathway

Source

Identifiers

PMID: 28300015
DOI: 10.1017/erm.2017.3

Genes

FRZB
CAPN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FRZB and melusin, overexpressed in LGMD2A, regulate integrin β1D isoform replacement altering myoblast fusion and the integrin-signalling pathway.PMID 28300015Read ↗

Frizzled related protein deficiency impairs muscle strength, gait and calpain 3 levelsSemantic proximity Read ↗

Interconnection between molecular regulators in LMNA related muscular dystrophySemantic proximity Read ↗

GDF11 and its receptor ALK4 independently modulate human myoblast migration and fusionSemantic proximity Read ↗

MBNL1 Regulates the Expression and Alternative Splicing of Genes Enriched in Cell Adhesion and ApoptosisSemantic proximity Read ↗

Laminin-α2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms.Semantic proximity Read ↗

The dystroglycan complex: From biology to cancerSemantic proximity Read ↗

Cell–matrix interactions in muscle diseaseSemantic proximity Read ↗

Mis-splicing of Tau exon 10 in myotonic dystrophy type 1 is reproduced by overexpression of CELF2 but not by MBNL1 silencingSemantic proximity Read ↗

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactomeSemantic proximity Read ↗

Melanoma cell adhesion molecule is a novel marker for human fetal myogenic cells and affects myoblast fusionSemantic proximity Read ↗

The Role of Integrin β1D Mislocalization in the Pathophysiology of Calpain 3-Related Limb–Girdle Muscular DystrophySemantic proximity Read ↗

Filamin 2 (FLN2): A Muscle-specific Sarcoglycan Interacting ProteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.