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Frizzled related protein deficiency impairs muscle strength, gait and calpain 3 levels

24 May 2020

Abstract excerpt

Abstract Background Limb-girdle muscular dystrophy recessive 1 calpain3-related (LGMDR1), previously known as LGMD2A, is a disease caused by mutations in the CAPN3 gene. It is characterized by progressive weakness and muscle degeneration. Frizzled related protein (FRZB), upregulated in LGMDR1, was identified as a key regulator of the crosstalk between Wnt and integrin signalling pathways. FRZB gene silencing...

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PMID: 32448375
DOI: 10.1186/s13023-020-01372-1

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