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Immune phenotype and function of natural killer and T cells in chronic hepatitis C patients who received a single dose of anti-MicroRNA-122, RG-101.

Hepatology (Baltimore, Md.) - 1 Jul 2017

Stelma Femke, van der Ree Meike H, Sinnige Marjan J, Brown Anthony, Swadling Leo, de Vree J Marleen L, Willemse Sophie B, van der Valk Marc, Grint Paul, Neben Steven, Klenerman Paul, Barnes Eleanor, Kootstra Neeltje A, Reesink Hendrik W

Abstract excerpt

MicroRNA-122 is an important host factor for the hepatitis C virus (HCV). Treatment with RG-101, an N-acetylgalactosamine-conjugated anti-microRNA-122 oligonucleotide, resulted in a significant viral load reduction in patients with chronic HCV infection. Here, we analyzed the effects of RG-101 therapy on antiviral immunity. Thirty-two chronic HCV patients infected with HCV genotypes 1, 3, and 4 received a single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28295463
DOI: 10.1002/hep.29148
PMCID: PMC5850982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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