Article
Peripheral blood mononuclear cells microRNA predicts treatment outcome of hepatitis C virus genotype 1 infection.
Antiviral research - 1 May 2014
Hsi Edward, Huang Chung-Feng, Dai Chia-Yen, Juo Suh-Hang Hank, Chou Wen-Wen, Huang Jee-Fu, Yeh Ming-Lun, Lin Zu-Yau, Chen Shinn-Cherng, Wang Liang-Yen, Chuang Wan-Long, Yu Ming-Lung
Abstract excerpt
BACKGROUNDS: Chronic hepatitis C virus (HCV) infection has been associated with induction of microRNAs (miRNAs) in peripheral blood mononuclear cells (PBMC). We aimed to evaluate the role of PBMC-miRNAs in the treatment outcome to antiviral therapy for HCV genotype 1 (HCV-1) patients. METHODS: Treatment-naive chronic HCV-1 patients, including 13 in screening phase and 48 in validation phase, were treated with...
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