Article
Fibroblast dynamics as an in vitro screening platform for anti-fibrotic drugs in primary myelofibrosis.
Journal of cellular physiology - 1 Jan 2018
Tomuleasa Ciprian, Selicean Sonia, Gafencu Grigore, Petrushev Bobe, Pop Laura, Berce Cristian, Jurj Anca, Trifa Adrian, Rosu Ana-Maria, Pasca Sergiu, Magdo Lorand, Zdrenghea Mihnea, Dima Delia, Tanase Alina, Frinc Ioana, Bojan Anca, Berindan-Neagoe Ioana, Ghiaur Gabriel, Ciurea Stefan O
Abstract excerpt
Although the cause for bone marrow fibrosis in patients with myelofibrosis remains controversial, it has been hypothesized that it is caused by extensive fibroblast proliferation under the influence of cytokines generated by the malignant megakaryocytes. Moreover, there is no known drug therapy which could reverse the process. We studied the fibroblasts in a novel system using the hanging drop method, evaluated...
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