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Article

PTPN22 -1123G>C polymorphism and anti-cyclic citrullinated protein antibodies in rheumatoid arthritis.

Medicina clinica - 10 Aug 2017

Muñoz-Valle José Francisco, Padilla-Gutiérrez Jorge Ramón, Hernández-Bello Jorge, Ruiz-Noa Yeniley, Valle Yeminia, Palafox-Sánchez Claudia Azucena, Parra-Rojas Isela, Gutiérrez-Ureña Sergio Ramón, Rangel-Villalobos Hector

Abstract excerpt

BACKGROUND AND OBJECTIVES: The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene encodes an important negative regulator of T-cell activation, lymphoid-specific phosphatase -Lyp- and has been associated with different autoimmune disorders. The PTPN22 -1123G>C polymorphism appears to affect the transcriptional control of this gene, but to date, the biological significance of this polymorphisms on...

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Source

Identifiers

PMID: 28291534
DOI: 10.1016/j.medcli.2017.01.025

Genes

PTPN22
ACR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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