Article
Polymorphisms of 5-HTT LPR and GNβ3 825C>T and Response to Antidepressant Treatment in Functional Dyspepsia: A Study from The Functional Dyspepsia Treatment Trial.
The American journal of gastroenterology - 1 Jun 2017
Saito Yuri A, Locke G Richard, Almazar Ann E, Bouras Ernest P, Howden Colin W, Lacy Brian E, DiBaise John K, Prather Charlene M, Abraham Bincy P, El-Serag Hashem B, Moayyedi Paul, Herrick Linda M, Szarka Lawrence A, Camilleri Michael, Hamilton Frank A, Schleck Cathy D, Tilkes Katherine E, Zinsmeister Alan R, Talley Nicholas J
Abstract excerpt
OBJECTIVES: The Functional Dyspepsia Treatment Trial reported that amitriptyline (AMI) was associated with adequate relief of functional dyspepsia (FD) symptoms, but the pharmacogenetics of antidepressant response in FD are not known. GNβ3 825C>T CC genotype has been previously linked to FD and TT genotype to antidepressant response in depression. The ss genotype of the 5-HTT LPR variant of the serotonin...
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