Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Assessment of ciliary phenotype in primary ciliary dyskinesia by micro-optical coherence tomography.

JCI insight - 9 Mar 2017

Solomon George M, Francis Richard, Chu Kengyeh K, Birket Susan E, Gabriel George, Trombley John E, Lemke Kristi L, Klena Nikolai, Turner Brett, Tearney Guillermo J, Lo Cecilia W, Rowe Steven M

Abstract excerpt

Ciliary motion defects cause defective mucociliary transport (MCT) in primary ciliary dyskinesia (PCD). Current diagnostic tests do not assess how MCT is affected by perturbation of ciliary motion. In this study, we sought to use micro-optical coherence tomography (μOCT) to delineate the mechanistic basis of cilia motion defects of PCD genes by functional categorization of cilia motion. Tracheae from three PCD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cilia
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ARC gene

Share to Kartagener Syndrome

Share to Phenotype

Share to Tomography, Optical Coherence

Source

Open in PubMed Open full text

Identifiers

PMID: 28289722
DOI: 10.1172/jci.insight.91702
PMCID: PMC5333960

Genes

ARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assessment of ciliary phenotype in primary ciliary dyskinesia by micro-optical coherence tomography.PMID 28289722Read ↗

Defining Functional Correction Thresholds in Primary Ciliary Dyskinesia for Effective Gene TherapiesSemantic proximity Read ↗

Machine Learning Analysis of Cilia-Driven Particle Transport Distinguishes Primary Ciliary Dyskinesia Cilia from Normal CiliaSemantic proximity Read ↗

Airway Disease in Children with Primary Ciliary Dyskinesia: Impact of Ciliary Ultrastructure Defect and Genotype.Semantic proximity Read ↗

The Cilialyzer – a freely available open-source software for a standardised identification of impaired mucociliary activity facilitating the diagnostic testing for PCDSemantic proximity Read ↗

Value of transmission electron microscopy for primary ciliary dyskinesia diagnosis in the era of molecular medicine: Genetic defects with normal and non-diagnostic ciliary ultrastructureSemantic proximity Read ↗

A quantitative super-resolution imaging toolbox for diagnosis of motile ciliopathies.Semantic proximity Read ↗

TTC25 Deficiency Results in Defects of the Outer Dynein Arm Docking Machinery and Primary Ciliary Dyskinesia with Left-Right Body Asymmetry Randomization.Semantic proximity Read ↗

Multiple Breath Washout in Primary Ciliary Dyskinesia: Potential for Lung Disease MonitoringSemantic proximity Read ↗

Deep phenotyping, including quantitative ciliary beating parameters, and extensive genotyping in primary ciliary dyskinesia.Semantic proximity Read ↗

Functional loss of Ccdc1 51 leads to hydrocephalus in a mouse model of primary ciliary dyskinesiaSemantic proximity Read ↗

Heterotaxy and complex structural heart defects in a mutant mouse model of primary ciliary dyskinesia.Semantic proximity Read ↗

Longitudinal Lung Volume Changes by Ultrastructure and Genotype in Primary Ciliary Dyskinesia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.