Article
Defining the in vivo phenotype of artemisinin-resistant falciparum malaria: a modelling approach.
PLoS medicine - 1 Apr 2015
White Lisa J, Flegg Jennifer A, Phyo Aung Pyae, Wiladpai-ngern Ja Hser, Bethell Delia, Plowe Christopher, Anderson Tim, Nkhoma Standwell, Nair Shalini, Tripura Rupam, Stepniewska Kasia, Pan-Ngum Wirichada, Silamut Kamolrat, Cooper Ben S, Lubell Yoel, Ashley Elizabeth A, Nguon Chea, Nosten François, White Nicholas J, Dondorp Arjen M
Abstract excerpt
BACKGROUND: Artemisinin-resistant falciparum malaria has emerged in Southeast Asia, posing a major threat to malaria control. It is characterised by delayed asexual-stage parasite clearance, which is the reference comparator for the molecular marker 'Kelch 13' and in vitro sensitivity tests. However, current cut-off values denoting slow clearance based on the proportion of individuals remaining parasitaemic on...
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