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Article

Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons.

Development (Cambridge, England) - 15 Apr 2017

Martín-Ibáñez Raquel, Pardo Mónica, Giralt Albert, Miguez Andrés, Guardia Inés, Marion-Poll Lucile, Herranz Cristina, Esgleas Miriam, Garcia-Díaz Barriga Gerardo, Edel Michael J, Vicario-Abejón Carlos, Alberch Jordi, Girault Jean-Antoine, Chan Susan, Kastner Philippe, Canals Josep M

Abstract excerpt

Here, we unravel the mechanism of action of the Ikaros family zinc finger protein Helios (He) during the development of striatal medium spiny neurons (MSNs). He regulates the second wave of striatal neurogenesis involved in the generation of striatopallidal neurons, which express dopamine 2 receptor and enkephalin. To exert this effect, He is expressed in neural progenitor cells (NPCs) keeping them in the G1/G0...

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Identifiers

PMID: 28289129
DOI: 10.1242/dev.138248
PMCID: PMC5399659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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