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Article

Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins.

The Journal of biological chemistry - 21 Apr 2017

Iwahori Satoko, Umaña Angie C, VanDeusen Halena R, Kalejta Robert F

Abstract excerpt

The human cytomegalovirus (HCMV)-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates the retinoblastoma (Rb) tumor suppressor. Here, we identify the other Rb family members p107 and p130 as novel targets of UL97. UL97 phosphorylates p107 and p130 thereby inhibiting their ability to repress the E2F-responsive E2F1 promoter. As with Rb, this phosphorylation, and the rescue of E2F-responsive...

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Identifiers

PMID: 28289097
DOI: 10.1074/jbc.M116.773150
PMCID: PMC5399109

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