Article
Human cytomegalovirus tegument protein pp150 acts as a cyclin A2-CDK-dependent sensor of the host cell cycle and differentiation state.
Proceedings of the National Academy of Sciences of the United States of America - 22 Oct 2013
Bogdanow Boris, Weisbach Henry, von Einem Jens, Straschewski Sarah, Voigt Sebastian, Winkler Michael, Hagemeier Christian, Wiebusch Lüder
Abstract excerpt
Upon cell entry, herpesviruses deliver a multitude of premade virion proteins to their hosts. The interplay between these incoming proteins and cell-specific regulatory factors dictates the outcome of infections at the cellular level. Here, we report a unique type of virion-host cell interaction that is essential for the cell cycle and differentiation state-dependent onset of human cytomegalovirus (HCMV) lytic...
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