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Article

Deep sequencing of HPV E6/E7 genes reveals loss of genotypic diversity and gain of clonal dominance in high-grade intraepithelial lesions of the cervix.

BMC genomics - 14 Mar 2017

Shen-Gunther Jane, Wang Yufeng, Lai Zhao, Poage Graham M, Perez Luis, Huang Tim H M

Abstract excerpt

BACKGROUND: Human papillomavirus (HPV) is the carcinogen of almost all invasive cervical cancer and a major cause of oral and other anogenital malignancies. HPV genotyping by dideoxy (Sanger) sequencing is currently the reference method of choice for clinical diagnostics. However, for samples with multiple HPV infections, genotype identification is singular and occasionally imprecise or indeterminable due to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28288568
DOI: 10.1186/s12864-017-3612-y
PMCID: PMC5348809

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