Article
Characterization and Diversity of 243 Complete Human Papillomavirus Genomes in Cervical Swabs Using Next Generation Sequencing.
Viruses - 14 Dec 2020
Latsuzbaia Ardashel, Wienecke-Baldacchino Anke, Tapp Jessica, Arbyn Marc, Karabegović Irma, Chen Zigui, Fischer Marc, Mühlschlegel Friedrich, Weyers Steven, Pesch Pascale, Mossong Joël
Abstract excerpt
In recent years, next generation sequencing (NGS) technology has been widely used for the discovery of novel human papillomavirus (HPV) genotypes, variant characterization and genotyping. Here, we compared the analytical performance of NGS with a commercial PCR-based assay (Anyplex II HPV28) in cervical samples of 744 women. Overall, HPV positivity was 50.2% by the Anyplex and 45.5% by the NGS. With the NGS, we...
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