Article
Characterization of Intra-Type Variants of Oncogenic Human Papillomaviruses by Next-Generation Deep Sequencing of the E6/E7 Region.
Viruses - 14 Mar 2016
Lavezzo Enrico, Masi Giulia, Toppo Stefano, Franchin Elisa, Gazzola Valentina, Sinigaglia Alessandro, Masiero Serena, Trevisan Marta, Pagni Silvana, Palù Giorgio, Barzon Luisa
Abstract excerpt
Different human papillomavirus (HPV) types are characterized by differences in tissue tropism and ability to promote cell proliferation and transformation. In addition, clinical and experimental studies have shown that some genetic variants/lineages of high-risk HPV (HR-HPV) types are characterized by increased oncogenic activity and probability to induce cancer. In this study, we designed and validated a new...
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