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The Association of Polymorphisms in Nrf2 and Genes Involved in Redox Homeostasis in the Development and Progression of Clear Cell Renal Cell Carcinoma.

Oxidative medicine and cellular longevity - 1 Jan 2021

Mihailovic Smiljana, Coric Vesna, Radic Tanja, Radojevic Ana Savic, Matic Marija, Dragicevic Dejan, Djokic Milica, Vasic Vladimir, Dzamic Zoran, Simic Tatjana, Hadzi-Djokic Jovan, Pljesa Ercegovac Marija

Abstract excerpt

Deleterious effects of SNPs found in genes encoding transcriptional factors, as well as antioxidant and detoxification enzymes, are disputable; however, their functional significance seems to modify the risk for clear cell renal cell carcinoma (ccRCC) development and progression. We investigated the effect of specific Nrf2, SOD2, GPX1 gene variants and GSTP1ABCD haplotype on ccRCC risk and prognosis and evaluated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33953831
DOI: 10.1155/2021/6617969
PMCID: PMC8068539

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