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Article

A SCN9A gene-encoded dorsal root ganglia sodium channel polymorphism associated with severe fibromyalgia.

BMC musculoskeletal disorders - 20 Feb 2012

Vargas-Alarcon Gilberto, Alvarez-Leon Edith, Fragoso Jose-Manuel, Vargas Angelica, Martinez Aline, Vallejo Maite, Martinez-Lavin Manuel

Abstract excerpt

BACKGROUND: A consistent line of investigation suggests that autonomic nervous system dysfunction may explain the multi-system features of fibromyalgia (FM); and that FM is a sympathetically maintained neuropathic pain syndrome. Dorsal root ganglia (DRG) are key sympathetic-nociceptive short-circuit sites. Sodium channels located in DRG (particularly Nav1.7) act as molecular gatekeepers for pain detection. Nav1.7...

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Identifiers

PMID: 22348792
DOI: 10.1186/1471-2474-13-23
PMCID: PMC3310736

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