Article
Treatment of Acute Myeloid Leukemia with the FLT3 Gene Mutation.
Current oncology reports - 1 Mar 2017
Best-Aguilera Carlos, Rodrigo Gómez-Vázquez O, Elizabeth Guzmán-Hernández A, Monserrat Rojas-Sotelo R
Abstract excerpt
In acute myeloid leukemia (AML), mutations of the Fms-like tyrosine kinase 3 receptor (FLT3) and its overexpression are related with hyperleukocytosis, higher risk of relapse, and decrease of both disease-free survival and overall survival. It has been suggested that this phenomenon confers proliferative and survival advantages to the malignant blast cells. As a consequence, it is an attractive therapeutic...
Topics
- Cell Proliferation
- Disease-Free Survival
- Humans
- Leukemia, Myeloid, Acute
- Molecular Targeted Therapy
- Mutation
- Protein Kinase Inhibitors
- fms-Like Tyrosine Kinase 3