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Article

Circulating gluten-specific FOXP3+CD39+ regulatory T cells have impaired suppressive function in patients with celiac disease.

The Journal of allergy and clinical immunology - 1 Dec 2017

Cook Laura, Munier C Mee Ling, Seddiki Nabila, van Bockel David, Ontiveros Noé, Hardy Melinda Y, Gillies Jana K, Levings Megan K, Reid Hugh H, Petersen Jan, Rossjohn Jamie, Anderson Robert P, Zaunders John J, Tye-Din Jason A, Kelleher Anthony D

Abstract excerpt

BACKGROUND: Celiac disease is a chronic immune-mediated inflammatory disorder of the gut triggered by dietary gluten. Although the effector T-cell response in patients with celiac disease has been well characterized, the role of regulatory T (Treg) cells in the loss of tolerance to gluten remains poorly understood. OBJECTIVE: We sought to define whether patients with celiac disease have a dysfunction or lack of...

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Source

Identifiers

PMID: 28283419
DOI: 10.1016/j.jaci.2017.02.015

Genes

FOXP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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