Article
Prognostic impact of c-Rel nuclear expression and REL amplification and crosstalk between c-Rel and the p53 pathway in diffuse large B-cell lymphoma.
Oncotarget - 15 Sept 2015
Li Ling, Xu-Monette Zijun Y, Ok Chi Young, Tzankov Alexandar, Manyam Ganiraju C, Sun Ruifang, Visco Carlo, Zhang Mingzhi, Montes-Moreno Santiago, Dybkaer Karen, Chiu April, Orazi Attilio, Zu Youli, Bhagat Govind, Richards Kristy L, Hsi Eric D, Choi William W L, van Krieken J Han, Huh Jooryung, Ponzoni Maurilio, Ferreri Andrés J M, Møller Michael B, Wang Jinfen, Parsons Ben M, Winter Jane N, Piris Miguel A, Pham Lan V, Medeiros L Jeffrey, Young Ken H
Abstract excerpt
Dysregulated NF-κB signaling is critical for lymphomagenesis. The regulation, function, and clinical relevance of c-Rel/NF-κB activation in diffuse large B-cell lymphoma (DLBCL) have not been well studied. In this study we analyzed the prognostic significance and gene-expression signature of c-Rel nuclear expression as surrogate of c-Rel activation in 460 patients with de novo DLBCL. Nuclear c-Rel expression,...
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