Article

IL-6 trans-signaling mediates cytokine secretion and barrier dysfunction in hantavirus infected cells and correlate to severity in HFRS

2024-08-17

Abstract excerpt

<h4>Background</h4> Hantavirus causes hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Strong inflammatory responses and vascular leakage are important hallmarks of these often fatal diseases. The mechanism behind pathogenesis is unknown and no specific treatment is available. IL-6 was recently highlighted as a biomarker for HPS/HFRS severity. IL-6 signaling is complex and cont...

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Literature Corpus work: f38830b5-f7a0-52b8-9cb0-edd14af32f92
DOI: 10.1101/2024.08.15.24312051

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