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Article

The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape.

G3 (Bethesda, Md.) - 5 May 2017

Percival Christopher J, Marangoni Pauline, Tapaltsyan Vagan, Klein Ophir, Hallgrímsson Benedikt

Abstract excerpt

Inbred genetic background significantly influences the expression of phenotypes associated with known genetic perturbations and can underlie variation in disease severity between individuals with the same mutation. However, the effect of epistatic interactions on the development of complex traits, such as craniofacial morphology, is poorly understood. Here, we investigated the effect of three inbred backgrounds...

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Share to Adaptor Proteins, Signal Transducing
Share to Craniofacial Abnormalities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Gene Expression Regulation, Developmental

Share to Genetic Background

Share to Intracellular Signaling Peptides and Proteins

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Share to Protein Serine-Threonine Kinases

Source

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Identifiers

PMID: 28280213
DOI: 10.1534/g3.117.040659
PMCID: PMC5427488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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