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USP7 deubiquitinase controls HIV-1 production by stabilizing Tat protein

9 Mar 2017

Abstract excerpt

Deubiquitinases (DUBs) are key regulators of complex cellular processes. HIV-1 Tat is synthesized early after infection and is mainly responsible for enhancing viral production. Here, we report that one of the DUBs, USP7, stabilized the HIV-1 Tat protein through its deubiquitination. Treatment with either a general DUB inhibitor (PR-619) or USP7-specific inhibitor (P5091) resulted in Tat protein degradation. The...

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PMID: 28280111
DOI: 10.1042/bcj20160304

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