Article
Oxidized Derivatives of Linoleic Acid in Pediatric Metabolic Syndrome: Is Their Pathogenic Role Modulated by the Genetic Background and the Gut Microbiota?
Antioxidants & redox signaling - 10 Jan 2019
Tricò Domenico, Di Sessa Anna, Caprio Sonia, Chalasani Naga, Liu Wanqing, Liang Tiebing, Graf Joerg, Herzog Raimund I, Johnson Casey D, Umano Giuseppina Rosaria, Feldstein Ariel E, Santoro Nicola
Abstract excerpt
We tested whether oxidized linoleic acid metabolites (OXLAM) are associated with pediatric metabolic syndrome (MetS) and a proatherogenic lipoprotein profile in 122 obese adolescents. Furthermore, we examined whether genetic and metagenomic factors can modulate plasma OXLAM concentrations by genotyping the fatty acid desaturase 1/2 (FADS) gene and by characterizing the gut microbiota. Subjects with MetS (n = 50)...
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