Article
A CEACAM6-High Airway Neutrophil Phenotype and CEACAM6-High Epithelial Cells Are Features of Severe Asthma.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2017
Shikotra Aarti, Choy David F, Siddiqui Salman, Arthur Greer, Nagarkar Deepti R, Jia Guiquan, Wright Adam K A, Ohri Chandra M, Doran Emma, Butler Claire A, Hargadon Beverley, Abbas Alexander R, Jackman Janet, Wu Lawren C, Heaney Liam G, Arron Joseph R, Bradding Peter
Abstract excerpt
Severe asthma represents a major unmet clinical need; understanding the pathophysiology is essential for the development of new therapies. Using microarray analysis, we previously found three immunological clusters in asthma: Th2-high, Th17-high, and Th2/17-low. Although new therapies are emerging for Th2-high disease, identifying molecular pathways in Th2-low disease remains an important goal. Further...
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