Article
Inactivation of tumor suppressor genes and cancer therapy: An evolutionary game theory approach.
Mathematical biosciences - 1 Jun 2017
Khadem Heydar, Kebriaei Hamed, Veisi Zahra
Abstract excerpt
Inactivation of alleles in tumor suppressor genes (TSG) is one of the important issues resulting in evolution of cancerous cells. In this paper, the evolution of healthy, one and two missed allele cells is modeled using the concept of evolutionary game theory and replicator dynamics. The proposed model also takes into account the interaction rates of the cells as designing parameters of the system. Different...
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