Article
Chronic myelomonocytic leukemia blast crisis in a patient with advanced non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors.
Respiratory investigation - 1 Mar 2017
Ogata Hiroaki, Okamoto Isamu, Yoshimoto Goichi, Obara Teppei, Ijichi Kayo, Iwama Eiji, Harada Taishi, Akashi Koichi, Nakanishi Yoichi
Abstract excerpt
A 59-year-old woman with epidermal growth factor receptor gene (EGFR) mutation-positive advanced lung adenocarcinoma was treated with afatinib after a diagnosis of chronic myelomonocytic leukemia (CMML). Twenty-one weeks later, she developed agranulocytosis, and CMML subsequently progressed to blast crisis. After complete remission of CMML, gefitinib was initiated; however, agranulocytosis recurred. This is the...
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