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Article

Diagnosing and managing advanced chronic myeloid leukemia.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting - 1 Jan 2015

Deininger Michael W

Abstract excerpt

Clinical staging of chronic myeloid leukemia (CML) distinguishes between chronic phase (CP-CML), accelerated phase (AP-CML), and blastic phase (BP-CML), reflecting its natural history in the absence of effective therapy. Morphologically, transformation from CP-CML to AP/BP-CML is characterized by a progressive or sudden loss of differentiation. Multiple different somatic mutations have been implicated in...

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Identifiers

PMID: 25993200
DOI: 10.14694/EdBook_AM.2015.35.e381

Genes

ABL1
BCR

Provenance

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