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Article

Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells

7 Mar 2017

Abstract excerpt

cancer stem cell (CSC)-enriched mesenchymal cells reside in an intermediate epithelial/mesenchymal phenotypic state. Among patients with TNBC who received chemotherapy, elevated ITGB4 expression was associated with a worse 5-year probability of relapse-free survival. Mechanistically, we find that the ZEB1 (zinc finger E-box binding homeobox 1) transcription factor activity in highly mesenchymal SUM159 TNBC cells...

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PMID: 28270621
DOI: 10.1073/pnas.1618298114

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