Article
Safety and Efficacy of a Topical Sodium Channel Inhibitor (TV-45070) in Patients With Postherpetic Neuralgia (PHN): A Randomized, Controlled, Proof-of-Concept, Crossover Study, With a Subgroup Analysis of the Nav1.7 R1150W Genotype.
The Clinical journal of pain - 1 Apr 2017
Price Nicola, Namdari Rostam, Neville Judith, Proctor Katie J W, Kaber Samer, Vest Jeffery, Fetell Michael, Malamut Richard, Sherrington Robin P, Pimstone Simon N, Goldberg Yigal P
Abstract excerpt
OBJECTIVE: The objective was to evaluate the safety and efficacy of TV-45070 ointment, as a treatment for postherpetic neuralgia, and to explore the response in patients with the Nav1.7 R1150W gain-of-function polymorphism. MATERIALS AND METHODS: This was a randomized, placebo-controlled, 2-period, 2-treatment crossover trial. Patients with postherpetic neuralgia with moderate or greater pain received TV-45070...
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