Article
Overexpression of wild-type p21Ras plays a prominent role in colorectal cancer.
International journal of molecular medicine - 1 Apr 2017
Bai Shuang, Feng Qiang, Pan Xin-Yan, Zou Hong, Chen Hao-Bin, Wang Peng, Zhou Xin-Liang, Hong Yan-Ling, Song Shu-Ling, Yang Ju-Lun
Abstract excerpt
Colorectal cancer (CRC) is the most common gastrointestinal type of cancer. The overexpression of Ras proteins, particularly p21Ras, are involved in the development of CRC. However, the subtypes of the p21Ras proteins that are overexpressed and the mutation status remain unknown restricting the development of therapeutic antibodies targeting p21Ras proteins. The present study aimed to investigate the mutation...
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