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Article

The influence of α-actinin-3 deficiency on bone remodelling markers in young men.

Bone - 1 May 2017

Levinger Itamar, Yan Xu, Bishop David, Houweling Peter J, Papadimitriou Ioannis, Munson Fiona, Byrnes Elizabeth, Vicari Daniele, Brennan-Speranza Tara C, Eynon Nir

Abstract excerpt

There is a large individual variation in the bone remodelling markers (BRMs) osteocalcin (OC), procollagen 1 N-terminal propeptide (P1NP) and β-isomerized C-terminal telopeptide (β-CTx), as well as undercarboxylated osteocalcin (ucOC), at rest and in response to exercise. α-actinin-3 (ACTN3), a sarcomeric protein, is expressed in skeletal muscle and osteoblasts and may influence BRM levels and the cross-talk...

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Source

Identifiers

PMID: 28254467
DOI: 10.1016/j.bone.2017.02.010

Genes

ACTN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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