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A “human knockout” model to investigate the influence of the α-actinin-3 protein on exercise-induced mitochondrial adaptations

3 Sept 2019

Abstract excerpt

Research in α-actinin-3 knockout mice suggests a novel role for α-actinin-3 as a mediator of cell signalling. We took advantage of naturally-occurring human "knockouts" (lacking α-actinin-3 protein) to investigate the consequences of α-actinin-3 deficiency on exercise-induced changes in mitochondrial-related genes and proteins, as well as endurance training adaptations. At baseline, we observed a compensatory...

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PMID: 31481717
DOI: 10.1038/s41598-019-49042-y

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