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Article

Role of Cyclooxygenase-2 Pathway in Creating an Immunosuppressive Microenvironment and in Initiation and Progression of Wilms' Tumor.

Neoplasia (New York, N.Y.) - 1 Mar 2017

Maturu Paramahamsa, Jones Devin, Ruteshouser E Cristy, Hu Qianghua, Reynolds Joseph M, Hicks John, Putluri Nagireddy, Ekmekcioglu Suhendan, Grimm Elizabeth A, Dong Chen, Overwijk Willem W

Abstract excerpt

Wilms' tumors (WT), which accountfor 6% of all childhood cancers, arise from dysregulated differentiation of nephrogenic progenitor cells from embryonic kidneys. Though there is an improvement in the prognosis of WT, still 10% of patients with WT die due to recurrence. Thus more effective treatment approaches are necessary. We previously characterized the inflammatory microenvironment in human WT and observed the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28254151
DOI: 10.1016/j.neo.2016.07.009
PMCID: PMC6197604

Genes

CCR5
CXCR4
STAT3
TNF

Provenance

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