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Article

Inhibition of Wilms' Tumor Proliferation and Invasion by Blocking TGF-β Receptor I in the TGF-β/Smad Signaling Pathway.

BioMed research international - 1 Jan 2020

Shi Qinlin, Wu Huan, Li Yonglin, Shen Lianju, Tian Xiaomao, Lin Tao, Wei Guanghui

Abstract excerpt

Wilms' tumor (WT) is a common embryonal tumor, and nephrogenic rests play a critical role in WT development. The transforming growth factor β (TGF-β) signaling pathway is fundamental to embryo development and cell growth and proliferation. Moreover, TGF-β contributes to WT development, but the mechanisms of disease pathogenicity are unknown. This study investigated whether the TGF-β signaling pathway was involved...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33282954
DOI: 10.1155/2020/8039840
PMCID: PMC7685794

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