Article
Interleukin-1 Receptor Antagonist Polymorphism and Birth Timing: Pathway Analysis Among African American Women.
Nursing research - 1 Jan 2000
Gillespie Shannon L, Neal Jeremy L, Christian Lisa M, Szalacha Laura A, McCarthy Donna O, Salsberry Pamela J
Abstract excerpt
BACKGROUND: Timing of birth is a major determinant of newborn health. African American women are at increased risk for early birth, particularly via the inflammatory pathway. Variants of the IL1RN gene, which encode the interleukin-1 receptor antagonist (IL-1Ra) protein, are implicated in early birth. The biological pathways linking these variables remain unclear. Evidence also suggests that inflammatory pathways...
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