Article
Molecular Confirmation of the Relationship between Candida guilliermondii Fks1p Naturally Occurring Amino Acid Substitutions and Its Intrinsic Reduced Echinocandin Susceptibility.
Antimicrobial agents and chemotherapy - 1 May 2017
Dudiuk Catiana, Macedo Daiana, Leonardelli Florencia, Theill Laura, Cabeza Matias S, Gamarra Soledad, Garcia-Effron Guillermo
Abstract excerpt
Candida guilliermondii shows intrinsic reduced echinocandin susceptibility. It harbors two polymorphisms (L633M and T634A) in the Fks1p hot spot 1 region. Our objective was to confirm that the reduced echinocandin susceptibility of C. guilliermondii is due to those naturally occurring substitutions. We constructed a Saccharomyces cerevisiae mutant in which a region of the FKS1 gene (including hot spot 1) was...
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