Article
CRISPR/Cas9-based efficient genome editing in Staphylococcus aureus.
Acta biochimica et biophysica Sinica - 1 Sept 2017
Liu Qi, Jiang Yu, Shao Lei, Yang Ping, Sun Bingbing, Yang Sheng, Chen Daijie
Abstract excerpt
Staphylococcus aureus is an important pathogenic bacterium prevalent in nosocomial infections and associated with high morbidity and mortality rates, which arise from the significant pathogenicity and multi-drug resistance. However, the typical genetic manipulation tools used to explore the relevant molecular mechanisms of S. aureus have multiple limitations: leaving a scar in the genome, comparatively low...
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