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Article

Laminin alpha1 chain reduces muscular dystrophy in laminin alpha2 chain deficient mice.

Human molecular genetics - 15 Aug 2004

Gawlik Kinga, Miyagoe-Suzuki Yuko, Ekblom Peter, Takeda Shin'ichi, Durbeej Madeleine

Abstract excerpt

Laminin (LN) alpha2 chain deficiency in humans and mice leads to severe forms of congenital muscular dystrophy (CMD). Here, we investigated whether LNalpha1 chain in mice can compensate for the absence of LNalpha2 chain and prevent the development of muscular dystrophy. We generated mice expressing a LNalpha1 chain transgene in skeletal muscle of LNalpha2 chain deficient mice. LNalpha1 is not normally expressed...

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Identifiers

PMID: 15213105
DOI: 10.1093/hmg/ddh190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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