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Article

Morpholino-based correction of hypomorphic ZAP70 mutation in an adult with combined immunodeficiency.

The Journal of allergy and clinical immunology - 1 May 2017

Gavino Christina, Landekic Marija, Zeng Jibin, Wu Ning, Jung Sungmi, Zhong Ming-Chao, Cohen-Blanchet Alexis, Langelier Mélanie, Neyret Odile, Lejtenyi Duncan, Rochefort Claudia, Cotton-Montpetit Judith, McCusker Christine, Mazer Bruce, Veillette André, Vinh Donald C

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28216435
DOI: 10.1016/j.jaci.2017.02.002
PMCID: PMC7126384

Genes

ZAP70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

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Morpholino-based correction of hypomorphic ZAP70 mutation in an adult with combined immunodeficiency.PMID 28216435Read ↗

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Novel Compound Heterozygous Mutations in ZAP70 Leading to a SCID Phenotype with Normal Downstream In vitro Signaling.Semantic proximity Read ↗

Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling.Semantic proximity Read ↗

SYK expression endows human ZAP70-deficient CD8 T cells with residual TCR signaling.Semantic proximity Read ↗

A novel hypomorphic ζ-chain-associated protein tyrosine kinase 70 kDa mutation with normal CD8+ T cells count.Semantic proximity Read ↗

Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase.Semantic proximity Read ↗

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinaseSemantic proximity Read ↗

A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity.Semantic proximity Read ↗

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