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Autophagy impairment byHelicobacter pylori-induced methylation silencing ofMAP1LC3Av1promotes gastric carcinogenesis

18 Feb 2017

Abstract excerpt

Helicobacter pylori (H. pylori) infection induces methylation silencing of tumor suppressor genes causing gastric carcinogenesis. Impairment of autophagy induces DNA damage leading to genetic instability and carcinogenesis. We aimed to identify whether H. pylori infection induced methylation silencing of host autophagy-related (Atg) genes, impairing autophagy and enhancing gastric carcinogenesis. Gastric mucosae...

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PMID: 28214334
DOI: 10.1002/ijc.30657

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