Helicobacter pylori inhibits autophagic flux and promotes its intracellular survival and colonization by down‐regulating SIRT1

Abstract excerpt

Helicobacter pylori (H. pylori) is the strong risk factor for a series of gastric pathological changes. Persistent colonization of H. pylori leading to chronic infection is responsible for gastritis and malignancy. Autophagy is an evolutionary conserved process which can protect cells and organisms from bacterial infection. Here, we demonstrated that H. pylori infection induced autophagosome formation but...

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