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Article

Acquisition of cancer stem cell-like properties in non-small cell lung cancer with acquired resistance to afatinib.

Cancer science - 1 Oct 2015

Hashida Shinsuke, Yamamoto Hiromasa, Shien Kazuhiko, Miyoshi Yuichiro, Ohtsuka Tomoaki, Suzawa Ken, Watanabe Mototsugu, Maki Yuho, Soh Junichi, Asano Hiroaki, Tsukuda Kazunori, Miyoshi Shinichiro, Toyooka Shinichi

Abstract excerpt

Afatinib is an irreversible epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) that is known to be effective against the EGFR T790M variant, which accounts for half of the mechanisms of acquired resistance to reversible EGFR-TKIs. However, acquired resistance to afatinib was...

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Source

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Identifiers

PMID: 26202045
DOI: 10.1111/cas.12749
PMCID: PMC4638008

Genes

EGFR
MET
ACR
ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26202045-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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