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The Somatic Impact on Inheritance and the Germline Control of the Soma

16 Jul 2025

Abstract excerpt

The faithful transmission of genomic DNA over succeeding generations is an essential prerequisite for species maintenance. The germplasm theory by August Weismann has been foundational for the current understanding of heredity; it proposed that genetic inheritance is exclusively mediated by germ cells while they are protecting heritable germline genomes from the phylogenetic influences of an individual's life...

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PMID: 40669498
DOI: 10.1146/annurev-genet-020325-040022

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